NFL odds, lines, picks, spreads, best bets, predictions for Week 1, 2021: Top model backing 49ers, Panthers

Table of Contents Top Week 1 NFL predictionsHow to make Week 1 NFL picks Week 1

Fresh off a 13-3 season and a trip to the AFC Championship Game, the Buffalo Bills will be tested to start the 2021 NFL schedule as they host the Pittsburgh Steelers. That’s one of five games between playoff teams from a season ago, and the Bills are 6.5-point favorites in the Week 1 NFL odds from Caesars Sportsbook. Only the Rams and 49ers are bigger favorites, with the Week 1 lines showing Los Angeles favored by 7.5 over Chicago and San Francisco favored by 8.5 over Detroit.

In addition to the five matchups between playoff teams, there are two divisional matchups, with the Jaguars favored by three over the Texans and the Patriots favored by a field goal over the Dolphins in the Week 1 NFL spreads. Which way should you lean on all 15 remaining games as you make your Week 1 NFL bets? All of the Week 1 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 1 NFL picks now

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 1 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 1 NFL predictions

One of the top Week 1 NFL predictions the model recommends: The 49ers (-8.5) cover the spread against the Lions. The 49ers have been one of the best road teams in the NFL, winning seven of their eight regular-season road games on their way to becoming NFC Champions two seasons ago and capturing five of their six overall wins on the road last year.

Meanwhile, the Lions only won once at home last season and Dan Campbell has been tasked with another difficult rebuild. The Lions finished 20th in scoring and total offense last season and replaced quarterback Matthew Stafford with Jared Goff. They also let wide receiver Kenny Golladay walk in free agency. That’s going to put a lot of pressure on a defense that ranked last in points allowed and yards allowed a season ago.

The model is expecting a healthy 49ers offense to pile up over 450 yards of total offense. The line has been moving towards San Francisco after opening at 7.5 points, but the visitors still cover in over 50 percent of SportsLine’s simulations.

Another one of the top Week 1 NFL picks from the model: The Panthers (-4) cover as home favorites against the Jets. After being selected by the Jets with the No. 3 overall in the 2018 NFL Draft and being traded away after just three seasons, Darnold will get an immediate chance at revenge with the Jets coming to visit him in his new home in Charlotte.

Darnold has looked comfortable in the preseason and is surrounded by far and away the most talented group of skill players he’s ever had. Christian McCaffrey is healthy after missing 13 games a season ago and should take the pressure off Darnold by powering a solid running game while also being arguably one of the most valuable receivers in the game too. The model predicts that McCaffrey piles up over 130 yards of total offense to help the Panthers cover in well over 50 percent of simulations.

How to make Week 1 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 1 NFL schedule, and it’s calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and find out.

Week 1 NFL odds (via Caesars)

Sunday, Sept. 12

Steelers at Bills (-6.5, 48)

Featured Game | Buffalo Bills vs. Pittsburgh Steelers

Jets at Panthers (-4, 44.5)

Featured Game | Carolina Panthers vs. New York Jets

Jaguars at Texans (+3, 45.5)

Featured Game | Houston Texans vs. Jacksonville Jaguars

Cardinals at Titans (-3. 53.5)

Featured Game | Tennessee Titans vs. Arizona Cardinals

Chargers at Washington (-1, 44.5)

Featured Game | Washington Football Team vs. Los Angeles Chargers

Eagles at Falcons (-3.5, 48.5)

Featured Game | Atlanta Falcons vs. Philadelphia Eagles

Seahawks at Colts (+3, 49)

Featured Game | Indianapolis Colts vs. Seattle Seahawks

Vikings at Bengals (+3, 47)

Featured Game | Cincinnati Bengals vs. Minnesota Vikings

49ers at Lions (+8.5, 46)

Featured Game | Detroit Lions vs. San Francisco 49ers

Browns at Chiefs (-5.5, 54.5)

Featured Game | Kansas City Chiefs vs. Cleveland Browns

Dolphins at Patriots (-3, 43.5)

Featured Game | New England Patriots vs. Miami Dolphins

Broncos at Giants (+3, 41.5)

Featured Game | New York Giants vs. Denver Broncos

Packers at Saints (+3.5, 49.5)

Featured Game | New Orleans Saints vs. Green Bay Packers

Bears at Rams (-7.5, 46.5)

Featured Game | Los Angeles Rams vs. Chicago Bears

Monday, Sept. 13

Ravens at Raiders (+4, 50.5)

Featured Game | Las Vegas Raiders vs. Baltimore Ravens